HPV: The First Discovery - HPV Hub, LLC

HPV: The First Discovery

Almost everyone will contract human papillomavirus (HPV) at some point in their lives. Fortunately, most cases result in no symptoms and will disappear on their own without treatment within two years. Some strains of HPV can cause warts to develop, but even these are relatively harmless for the most part.

Unfortunately, HPV also has the potential to cause serious health issues. The virus is responsible for virtually all cervical cancer cases. Additionally, HPV infections increase the risk of developing throat cancer and anal cancer.

While we understand the link between HPV and cancer today, the connection wasn’t always so clear. It took decades of research to discover exactly how HPV affects the body, particularly when it comes to cervical cancer.

A Surprising Connection

In the 1950s, scientists searching for possible causes of cervical cancer began looking into lifestyle factors which may be linked to the disease. They discovered that women who had multiple sexual partners or who had become sexually active at a younger age exhibited higher rates of cervical cancer. The results demonstrated a pattern similar to that of a sexually transmitted infection (STI).

This baffled scientists at the time, especially since cancer didn’t appear to be contagious. However, a virologist from Germany named Harald zur Hausen was intrigued.

Harold zur Hausen (courtesy of Nobelprize.org)

Zur Hausen had previously studied the cancer-causing Epstein-Barr virus, and he had read 1930s reports from American researcher Richard Shope in which a certain type of papillomavirus infection in rabbits led to the development of warts and then cancer. When reviewing medical cases in which women with genital warts developed cervical cancer, he realized a similar connection may exist. The next step was to find out if his theory was correct.

New Types of HPV

At the time, some scientists believed that herpes-simplex virus type 2 (HSV-2), an STI known to cause genital warts, was a possible cause of cervical cancer. However, Zur Hausen wanted to conduct his own research to investigate this further. He found that HSV-2 was not common in cervical cancer tumor samples, so he turned his attention to HPV and first published his hypothesis in 1976.

During the course of his research, Zur Hausen discovered several new types of papillomavirus, including HPV-6 and HPV-11. However, he found that neither type was strongly linked to cervical cancer. It wasn’t until 1983 and 1984, when Zur Hausen discovered two more HPV strains (HPV-16 and HPV-18) that the connection became clear.

Zur Hausen and his team of researchers soon discovered that HPV-16 was found in 50% of all cervical cancers, and HPV-18 was detected in 20% of cervical cancer samples. The fact that infection with human papillomaviruses, specifically HPV-16 and HPV-18, were closely linked to cervical cancer was a profound discovery. Today, we know that HPV-16 and HPV-18 are responsible for about 70% of cervical cancers worldwide.

Zur Hausen continued his research and advocated for an HPV vaccine beginning in 1986. The William B. Coley Award for Distinguished Research in Basic and Tumor Immunology was awarded to Zur Hausen in 2006, and in 2008, he won the Nobel Prize in Physiology or Medicine.

The Fight Against Cervical Cancer

After Zur Hausen’s discovery in the 1980s, researchers around the world found additional types of the HPV virus potentially linked to cervical cancers. In 1995, the International Biological Study on Cervical Cancer group was organized to piece all of these findings together. By compiling the samples from 22 different countries, they discovered that HPV was found in 93% of cervical cancer samples.

Further research confirmed these findings and actually proved that the initial figure was underestimated. In 1999, a group of scientists undertook a rigorous study in which they re-tested the samples. They found that HPV was present in virtually all cervical cancers (99.7%), proving that HPV infection is the cause of cervical cancer.

Though scientists have identified over a hundred types of HPV, there are only 13 high-risk types linked to cancer. Additionally, scientists discovered that genital warts are caused by different types of HPV than the high-risk, cancer-causing strains.

Fortunately, most women infected with high-risk HPV will not develop cervical cancer. With current testing and treatment options, those who do develop cancer have a better chance of survival. And as HPV vaccination becomes more widespread, the rates of cervical cancer continue to drop; in fact, Australia is expected to eliminate cervical cancer within 15 years due to the country’s robust screening and vaccination program. Thanks to decades of research from dedicated scientists, today’s women have a better chance of avoiding or beating cervical cancer than ever before.

Sources:
  1. Harald zur Hausen (1936–): The Embryo Project Encyclopedia, 2017.
  2. Milestones in Cancer Research and Discovery: National Cancer Institute, 2020.
  3. Integration and methylation of shope papilloma virus DNA in the transplantable V×2 and V×7 rabbit carcinomas: ScienceDirect, 1983.
  4. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers: National Center for Biotechnology Information, 1983.
  5. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions: National Center for Biotechnology Information, 1983.
  6. Cervical Cancer Screening: Pap and HPV Tests: National Cervical Cancer Coalition, 2020.
  7. Harald zur Hausen Facts: The Nobel Prize, 2020.
  8. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group: National Center for Biotechnology Information, 1995.
  9. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide: National Center for Biotechnology Information, 1999.
  10. Basic Information about HPV and Cancer: Centers for Disease Control and Prevention, 2018.
  11. Australia set to eliminate cervical cancer by 2035: Cancer Council, 2018.